Domingo de Acassuso (1658–1727) was a Spanish politician and military man, who served as mayor of Buenos Aires in 1716. He was the founder of the city of San Isidro in Buenos Aires Province.

Thomas W. Piper (April 22, 1849 – May 26, 1876), known as The Boston Belfry Murderer, was a Canadian-born American murderer who murdered two underage girls between 1873 and 1875 in Massachusetts and confessed to having done such to one other.

Luigi Lucheni (born Louis Lucheni; 22 April 1873 – 19 October 1910) was an Italian anarchist and the assassin of Empress Elisabeth of Austria.

Antonio Nirta (22 April 1919 – 1 September 2015) was a boss of the 'Ndrangheta, a Mafia-type organization, in the Italian region of Calabria. Together with his brothers Giuseppe, Francesco, and Sebastiano, he ruled San Luca, a stronghold of the 'Ndrangheta.

Henri Lafont (born Henri Chamberlin, 22 April 1902 – 26 December 1944) was an underworld figure who headed the Carlingue, French auxiliaries for the German security services, during the German occupation of France in World War II.

Vladimir Anatolyevich Mukhankin (Russian: Владимир Анатольевич Муханкин, born 22 April 1960) is a Russian serial killer, convicted for the murder of 9 people in Rostov Oblast in 1995.

Adam Peter Lanza (April 22, 1992 – December 14, 2012) was an American mass murderer responsible for the Sandy Hook Elementary School shooting, one of the deadliest mass shootings in the US. On December 14, 2012, he fatally shot his mother, Nancy Lanza, at their home in Newtown, Connecticut, before driving to Sandy Hook Elementary School, where he killed 20 children between the ages of six and seven, and six adult staff members.

Nikolay Alexandrovich Sakharov (Russian: Никола́й Алекса́ндрович Са́харов; 22 April 1954 – 5 February 1979), known as The Vologda Ripper (Russian: Вологодский потрошитель), was a Soviet serial killer, who became a figurant of one of the most high-profile trials in Vologda.

Vladimir Ilyich Ulyanov (22 April [O.S. 10 April] 1870 – 21 January 1924), better known as Vladimir Lenin, was a Russian revolutionary, politician and political theorist.